A population-based study on the causes of mild and severe mental retardation.
The causes of mental retardation (MR) were studied as part of a multidisciplinary epidemiological case-control study in 151 mentally retarded patients identified by screening four age cohorts (12882 children) at 8-9 years of age in the province of Kuopio, Finland.
The causes of MR in 77 severely retarded (SD¾-3 SD) and 74 mildly retarded (-2>SD>-3) children were divided into pre-peri-postnatal and unknown groups according to the probable time of onset.
The causes were pre-peri-postnatal and unknown in 60%, 9%, 8% and 23%, and 22%, 1%, 3% and 74%, in the two populations, respectively.
Genetic causes were found in 28% of all 151 cases ; the three most common subgroups were trisomy 21, fragile X syndrome and aspartylglycosaminuria (13%, 4% and 2% respectively).
The study design used provided reliable information on the causes of MR and also demonstrated those forms of genetic metabolic diseases typical of Finnish inheritance.
Mots-clés Pascal : Arriération mentale, Enfant, Homme, Epidémiologie, Finlande, Europe, Etiologie, Etude cohorte, Déficience intellectuelle
Mots-clés Pascal anglais : Mental retardation, Child, Human, Epidemiology, Finland, Europe, Etiology, Cohort study, Intellectual deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0246109
Code Inist : 002B17A01. Création : 09/06/1995.