We have compared the bronchial responsiveness (BR) of 12 aluminum potroom workers (index group) who were relocated due to work-related asthmatic symptoms (WASTH) and 26 subjects (reference group) with WASTH who continued to work in potrooms.
The subjects were examined at regular intervals during a 2-year follow-up period.
BR was expressed as the log-transformed dose-response slope [Ln (DRS+0.5) ]. The monthly change in BR (deltaBR) in the index group was - 4.87 x 10-2 compared with - 1.58 x 10-2 in the reference group.
After adjustment for potential confounders, the difference between the index group and the reference group was - 2.39 x 10-2 (95% CI : - 4.07 x 10-2 to - 0.71 x 10-2), i.e. 49% of the decrease in BR in the index group could be explained by the removal from exposure.
No improvement in lung function was found in the index group compared with the reference group.
The results indicate that the removal of potroom workers from exposure causes a decrease in BR.
Mots-clés Pascal : Aluminium, Métal, Exposition professionnelle, Asthme, Homme, Test provocation, Fonction respiratoire, Etude longitudinale, Activité professionnelle, Temps exposition, Médecine travail, Appareil respiratoire pathologie, Bronchopneumopathie obstructive
Mots-clés Pascal anglais : Aluminium, Metal, Occupational exposure, Asthma, Human, Provocation test, Lung function, Follow up study, Professional activity, Exposure time, Occupational medicine, Respiratory disease, Obstructive pulmonary disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0244913
Code Inist : 002B03L05. Création : 09/06/1995.