Carbon disulphide. II : Investigations on the uptake of CS2 and the excretion of its metabolite 2-thiothiazolidine-4-carboxylic acid after occupational exposure.
The reported investigations on the uptake of carbon disulphide (CS2) and the excretion of its metabolite 2-thiothiazolidine-4-carboxylic acid (TTCA) were based on results from 403 personal air samples (352 passive and 51 active samples) and 362 TTCA determinations in biological material measured during a field study on the adverse effects due to CS2 exposure.
The external exposure ranged from below the detection limit (0.2 ppm) to 66 ppm and the urinary TTCA excretion from below the detection limit (0.16 mg./1) to 33.4 mg/1. The excretion of TTCA in postshift urine related to creatinine and volume showed a linear correlation to the CS2 air concentration.
On the basis of these results the influence on the internal exposure of physical work load, dermal exposure and individual parameters (age, Brocaindex, disturbed skin barrier) was evaluated.
Correlations between the TTCA values in the postshift urine and the individually measured CS2 concentrations were carried out separately for individual departments and persons with and without indications of a disturbed skin barrier.
In order to be able to judge the individual internal exposure related to external exposure, a personal quotient was formed from the TTCA level in the urine and the CS2 air concentration measured on the same day (relative interal exposure RIE index=TTCA mg/g creatinine/CS2 in ppm).
Mots-clés Pascal : Carbone disulfure, Exposition professionnelle, Homme, Toxicocinétique, Surveillance biologique, Métabolisme, Teneur air ambiant, Lieu travail, Contrôle, Comparaison interindividuelle, Voie externe, Peau, Médecine travail
Mots-clés Pascal anglais : Carbon disulfide, Occupational exposure, Human, Toxicokinetics, Biological monitoring, Metabolism, Ambient air concentration, Work place, Check, Interindividual comparison, Topical administration, Skin, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0244906
Code Inist : 002B03L02. Création : 09/06/1995.