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  1. Cutaneous leishmaniasis in the Peruvian Andes : an epidemiological study of infection and immunity.

    Article - En anglais

    A prospective longitudinal survey of cutaneous leishmaniasis (Leishmania peruviana) was carried out in Peru on a study population of 4716 persons living in 38 villages (Departments of Lima, Ancash and Piura).

    Demographic and clinical data were collected from all individuals, and a Montenegro skin test (MST) was carried out on 72% (3418) of the study population.

    Each household was revisited at 3-monthly intervals for up to 2 years to detect new leishmaniasis cases ; 497 people received a second MST at the end of the study.

    Analysis of the epidemiological data indicated that (i) 17% (16/94) of all infections were subclinical, (ii) this percentage increased significantly with age, (iii) clinical infections led to 73.9% protective immunity (95% C.I. 53.0-85.5%) and relatively permanent MST responsiveness (recovery rate=0.0098/year ; 95% C.I. 0.000-0.020/year), (iv) sub-clinical infections led to protective immunity, which was positively correlated with their MST induration size (increasing by 17.9% per mm ; P<0.0001), and a mean MST recovery rate of 0.114/year (4/421 man-months), and (v) recurrent leishmaniasis was dominated by reactivations, not by reinfections.

    Mots-clés Pascal : Leishmaniose, Protozoose, Parasitose, Infection, Peau, Leishmania peruviana, Rhizoflagellata, Protozoa, Epidémiologie, Immunité, Etude longitudinale, Homme, Pérou, Amérique du Sud, Amérique

    Mots-clés Pascal anglais : Leishmaniasis, Protozoal disease, Parasitosis, Infection, Skin, Leishmania peruviana, Rhizoflagellata, Protozoa, Epidemiology, Immunity, Follow up study, Human, Peru, South America, America

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0243608

    Code Inist : 002B05E02B3. Création : 09/06/1995.