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  1. Human breast sarcoma and human breast implantation : a time trend analysis based on seer data (1973-1990) : Silicone breast implants and long-term health effects.

    Article - En anglais

    Since the demonstration in the 1940s of foreign body induction of sarcomas in rodents, the safety of artificial implants in humans has been a matter of concern.

    In this study, we assess the risk for the development of breast sarcomas in women with silicone breast implants.

    Our analysis is based on the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program database for the years 1973-1990 and on estimates of breast implantation rates from about 1960 onward.

    We have divided the SEER data into two equal time periods, 1972-1981 and 1982-1990.

    For each time period, we estimated the average annual number of women in the United States who had received breast implants 10 or more years earlier.

    This analysis allows for a 10 year latency period for the induction of breast sarcoma.

    We calculated that the average number of women in the U.S. 10 or more years post breast implantation was 55,000 for the 1973-1981 period and 509,000 for the 1982-1990 period.

    We then examined the SEER data to observe whether there was a concomitant rise in the female breast sarcoma incidence rates between these two time periods.

    We found the mean age-adjusted incidence rate of breast sarcomas was 0.13 per 100,000 women for the initial 9-year period, 1973-1981, and 0.12 per 100,000 women for the latter 9-year period, 1981-1990.

    Mots-clés Pascal : Sarcome, Glande mammaire, Prothèse, Siloxane polymère, Chirurgie plastique, Complication, Homme, Femelle, Epidémiologie, Evolution, Etats Unis, Amérique du Nord, Amérique, Tumeur maligne, Glande mammaire pathologie

    Mots-clés Pascal anglais : Sarcoma, Mammary gland, Prosthesis, Siloxane polymer, Plastic surgery, Complication, Human, Female, Epidemiology, Evolution, United States, North America, America, Malignant tumor, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0241784

    Code Inist : 002B20E02. Création : 09/06/1995.