In order to assess the present hepatitis B immunization program in Stockholm, Sweden, 212 children of HBsAg carrier mothers were followed up 2-9 gears after birth.
In babies of HBsAg-positive mothers a dombined passive and active immunization schedule with hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine was used.
Among 25 children to such mothers, 1 HBsAg carrier and 5 children with asymptomatic seroconversion were found.
To newborns of HBeAg-negative/anti-HBe-negative mothers, only vaccine was given.
Among 15 such children, no HBsAg carrier (but 1 child with an asymptomatic seroconversion) was found.
In babies of HBeAg-negative/anti-HBe-positive mothers, immunization was withheld between 1983 and 1987.
Among 90 such children, 1 HBsAg carrier and 8 asymptomatic seroconversions were detected.
After 1987, newborns in this group were vaccinated whereafter 3 asymptomatic seroconverstions were found among 82 children.
We conclude that in low prevalence areas a screening program for HBsAg should be offered to pregnant women originating from hepatitis B endemic regions, single immunoprophylaxis gave long-term protection to most children at risk.
Children born to HBeAg-positive mothers should receive vaccine in combination with HBIg, whereas for children of mothers lacking HBeAg, vaccination only seems sufficient, at least if a rapid vaccination schedule is used.
Mots-clés Pascal : Hépatite virale B, Virose, Infection, Immunoprophylaxie, Programme sanitaire, Mère pathologie, Vaccination, Prévention, Nouveau né, Homme, Nourrisson, Long terme, Etude longitudinale, Suède, Europe, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis B, Viral disease, Infection, Immunoprophylaxis, Sanitary program, Maternal diseases, Vaccination, Prevention, Newborn, Human, Infant, Long term, Follow up study, Sweden, Europe, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0232111
Code Inist : 002B05C02G. Création : 09/06/1995.