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  1. Prevention of hepatitis B by immunization of the newborn infant : a long-term follow-up study in Stockholm, Sweden.

    Article - En anglais

    In order to assess the present hepatitis B immunization program in Stockholm, Sweden, 212 children of HBsAg carrier mothers were followed up 2-9 gears after birth.

    In babies of HBsAg-positive mothers a dombined passive and active immunization schedule with hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine was used.

    Among 25 children to such mothers, 1 HBsAg carrier and 5 children with asymptomatic seroconversion were found.

    To newborns of HBeAg-negative/anti-HBe-negative mothers, only vaccine was given.

    Among 15 such children, no HBsAg carrier (but 1 child with an asymptomatic seroconversion) was found.

    In babies of HBeAg-negative/anti-HBe-positive mothers, immunization was withheld between 1983 and 1987.

    Among 90 such children, 1 HBsAg carrier and 8 asymptomatic seroconversions were detected.

    After 1987, newborns in this group were vaccinated whereafter 3 asymptomatic seroconverstions were found among 82 children.

    We conclude that in low prevalence areas a screening program for HBsAg should be offered to pregnant women originating from hepatitis B endemic regions, single immunoprophylaxis gave long-term protection to most children at risk.

    Children born to HBeAg-positive mothers should receive vaccine in combination with HBIg, whereas for children of mothers lacking HBeAg, vaccination only seems sufficient, at least if a rapid vaccination schedule is used.

    Mots-clés Pascal : Hépatite virale B, Virose, Infection, Immunoprophylaxie, Programme sanitaire, Mère pathologie, Vaccination, Prévention, Nouveau né, Homme, Nourrisson, Long terme, Etude longitudinale, Suède, Europe, Appareil digestif pathologie, Foie pathologie

    Mots-clés Pascal anglais : Viral hepatitis B, Viral disease, Infection, Immunoprophylaxis, Sanitary program, Maternal diseases, Vaccination, Prevention, Newborn, Human, Infant, Long term, Follow up study, Sweden, Europe, Digestive diseases, Hepatic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0232111

    Code Inist : 002B05C02G. Création : 09/06/1995.