The relation between performance on the digit symbol substitution test and subsequent 5-year mortality was examined in 1,118 male participants in the Western Collaborative Group Study (mean age at time of examination=70.6 years).
Cox regression analyses revealed that the unadjusted relative risk from all-cause mortality was 1.79 (95% confidence interval 1.45-2.21) for subjects who scored 10 points (1 standard deviation) lower on the digit symbol substitution test.
The relative risk remained significant at 1.44 (95% confidence interval 1.12-1.86) after adjustment for age, education, baseline serum cholesterol, and systolic blood pressure levels and for the prevalence of cancer, cardiovascular/cerebrovascular disease, and ever smoking.
Tree-structured survival analysis revealed the presence of a subgroup of subjects (n=130) with low digit symbol substitution performance (mean=26.3) who experienced a mortality rate of 34.9 deaths per 1,000 person-years.
This mortality rate was not significantly different from that encountered by another subgroup of subjects with a history of cancer (n=128 ; 45.7 deaths per 1,000 person-years).
If age-related slowing of information processing is a marker for aging of the central nervous system, then people with lower digit symbol scores may be « older » physiologically than similarly aged persons with higher digit symbol scores.
Mots-clés Pascal : Mortalité, Survie, Homme, Epidémiologie, Cognition, Performance, Psychomotricité, Sénescence, Californie, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Mortality, Survival, Human, Epidemiology, Cognition, Performance, Psychomotricity, Senescence, California, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0230431
Code Inist : 002B30A01A2. Création : 09/06/1995.