Case-control study of bladder cancer and arsenic in drinking water.
Mortality from several cancers, including bladder cancer, is elevated in a Taiwanese population exposed to high levels of arsenic in drinking water.
Data from the Utah respondents to the National Bladder Cancer Study conducted in 1978 were used to evaluate these associations in a US population exposed to measurable, but much lower, levels of drinking water arsenic.
Two indices of cumulative arsenic exposure were used, one representing total cumulative exposure (index 1) and the other, intake concentration (index 2).
Overall, there was no association of bladder cancer with either measure ; however, among smokers, but not among nonsmokers, positive trends in risk were found for exposures estimated for decade-long time periods, especially in the 30-to 39-year period prior to diagnosis.
Exposures were in the range 0.5-160 mug/liter (mean, 5.0 mug/liter).
The data raise the possibility that smoking potentiates the effect of arsenic on risk of bladder cancer.
However, the risk estimates obtained are much higher than predicted on the basis of the results of the Taiwanese studies, raising concerns about bias or the role of chance.
Confirmatory studies are needed.
Mots-clés Pascal : Tumeur maligne, Vessie urinaire, Epidémiologie, Arsenic, Contamination, Eau potable, Homme, Réseau adduction eau, Utah, Etats Unis, Amérique du Nord, Amérique, Toxicité, Carcinogène, Appareil urinaire pathologie, Voie urinaire pathologie, Etude cas témoin
Mots-clés Pascal anglais : Malignant tumor, Urinary bladder, Epidemiology, Arsenic, Contamination, Drinking water, Human, Water supply system network, Utah, United States, North America, America, Toxicity, Carcinogen, Urinary system disease, Urinary tract disease, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0228588
Code Inist : 002B14D02. Création : 09/06/1995.