Nonsteroidal anti-inflammatory drugs and the incidence of hospitalizations for peptic ulcer disease in elderly persons.
To determine the incidence rate of serious ulcer disease among users and nonusers of nonsteroidal anti-inflammatory drugs (NSAIDs), a retrospective cohort study was done on 103,954 elderly Tennessee Medicaid recipients with 209,068 person-years of follow-up from 1984 to 1986.
There were 1,371 patients hospitalized with peptic ulcer disease or upper gastrointestinal hemorrhage identified by Medicaid hospital claims and verified by review of the medical record.
Ulcer hospitalization rates by NSAID exposure category, duration of use, and daily dose were determined.
The rates of ulcer hospitalization among nonusers and current users of NSAIDs were 4.2 and 16.7 per 1,000 person-years, respectively, an excess rate among current users of 12.5 (95% confidence interval (CI) 11.4-13.6) per 1,000 person-years.
Among new users, the ulcer hospitalization rates were 26.3 per 1,000 person-years during the first 30 days of use and 20.9 per 1,000 person-years over the next 31-180 days, representing excess ulcer hospitalization rates of 22.1 (95% CI 18.6-25.6) and 1 6.7 (95% CI 13.1 - 20.1) per 1,000 person-years, respectively.
For long-term users (180 days or more of continuous NSAID use), the ulcer hospitalization rate remained elevated at 15.3, an excess of 12.0 (95% CI 10.3-13.6) hospitalizations per 1,000 person-years.
Mots-clés Pascal : Ulcère, Estomac, Toxicité, Antiinflammatoire non stéroïde, Hospitalisation, Vieillard, Homme, Hémorragie, Gastrointestinal, Epidémiologie, Tennessee, Etats Unis, Amérique du Nord, Amérique, Etude cohorte, Rétrospective, Estomac pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Ulcer, Stomach, Toxicity, Non steroidal antiinflammatory agent, Hospitalization, Elderly, Human, Hemorrhage, Gastrointestinal, Epidemiology, Tennessee, United States, North America, America, Cohort study, Retrospective, Gastric disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0228586
Code Inist : 002B02U04. Création : 09/06/1995.