This paper proposes the use of two-factor models (age-period and age-cohort models) to estimate age, period, and cohort effects on pulmonary function by using the data collected in a 24-year longitudinal study in the Netherlands from 1965 to 1990.
The analysis included 18,363 pulmonary function measurements on 6,148 subjects aged 20-54 years at the initial visit.
The subjects were grouped into four birth cohorts (before 1923,1923-1934,1935-1946, and after 1946) and four survey periods (1965-1972,1973-1978,1979-1984 and 1985-1990).
In the age-cohort model, the decrement in forced expiratory volume in 1 second (FEV1) associated with a yearly increase in age was 28.3±3.7 ml/year for a man 176 cm tall and 16.0±1.9 ml/year for a woman 163 cm tall.
The estimated acceleration of decline with aging was significant for both men (bêta=-0.212 ; standard error=0.079 ml) and women (n=-0.346 ; standard error=0.058 ml).
Compared with that of the cohort born before 1923, the average level of FEV1 was estimated to increase by 156,277, and 379 ml, respectively, for the three younger cohorts in men (p=0.01) and by 133,213, and 328 ml for the three younger cohorts in women (p<0.01).
Mots-clés Pascal : Fonction respiratoire, Appareil respiratoire pathologie, Homme, Epidémiologie, Etude longitudinale, Age, Modèle, Pays Bas, Europe, Méthode statistique, Méthode étude, Sexe
Mots-clés Pascal anglais : Lung function, Respiratory disease, Human, Epidemiology, Follow up study, Age, Models, Netherlands, Europe, Statistical method, Investigation method, Sex
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0228580
Code Inist : 002B11D. Création : 09/06/1995.