Gender and treatment outcome in childhood lymphoplastic leukaemia : report from the MRC UKALL trials.
We have examined the factors influencing prognosis in over 4000 children with acute lymphoblastic leukaemia (ALL) aged 1-14 who have been treated on consecutive MRC UKALL trials from 1972 to 1990.
During this time the results of treatment have improved steadily but are consistently superior in girls when compared with boys ; the 5-year event-free survival in girls improving from 51% to 71% and in boys from 31% to 57%. These results were independent of age and presenting leucocyte count.
Boys not only had a testicular relapse rate of 10% but an excess of bone marrow relapse, particularly evident after 2 years from diagnosis.
Other prognostic factors included organomegaly and the morphology of leukaemic blast cells ; immunophenotype of the leukaemia, however, had no independent significance after allowance for age, sex and leucocyte count.
The influence of sex on prognosis was reaffirmed when we examined various methods of identifying children at highest risk of treatment failure for whom alternative therapy such as bone marrow transplantation might be justified.
Mots-clés Pascal : Leucémie lymphoblastique, Enfant, Homme, Adolescent, Pronostic, Traitement, Résultat, Survie, Sexe, Etude comparative, Epidémiologie, Aigu, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Acute lymphocytic leukemia, Child, Human, Adolescent, Prognosis, Treatment, Result, Survival, Sex, Comparative study, Epidemiology, Acute, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0228210
Code Inist : 002B19B. Création : 09/06/1995.