The dispute between ancient and modern. Satellite symposium - Specificity of serotonin disturbances in depression and anxiety. Satellite symposium. Washington DC USA ; Marbella ESP, 1994/06/27 - 1992/10/18.
In an open multicentre study designed to closely reflect the clinical situation, 315 out-patients diagnosed by their psychiatrist as having depression and/or obsessive-compulsive disorder (OCD), and/or panic disorder, were treated for 12 weeks with fluvoxamine (100-300 mg/day).
Twelve weeks of fluvoxamine therapy was completed by 229 (73%) patients.
Longer illness duration prior to treatment was associated with a significantly reduced rate of treatment withdrawal, whereas a diagnosis of OCD was predictive of treatment withdrawal.
The main reasons patients discontinued fluvoxamine therapy were adverse effects experienced before Week 8, and clinical improvement thereafter.
Age, sex, and diagnosis bad no predictive value for treatment outcome ; however, psychiatric antecedents and duration and severity of illness at baseline were significant predictors of disease severity at endpoint.
Fluvoxamine decreased both the frequency and severity of baseline symptoms, with improvement continuing for the duration of the study.
Nausea was the only symptom to show an initial increase in frequency and severity, but this subsided after 4 weeks to levels below baseline frequency and severity.
Mots-clés Pascal : Antidépresseur, Psychotrope, Tranquillisant, Chimiothérapie, Efficacité traitement, Homme, Neuromédiateur, Fluvoxamine, Inhibiteur recapture, Sérotonine, Etat dépressif, Trouble humeur, Panique, Obsession compulsion, Trouble anxieux, Etude multicentrique, Epidémiologie, Belgique, Europe
Mots-clés Pascal anglais : Antidepressant agent, Psychotropic, Tranquillizer, Chemotherapy, Treatment efficiency, Human, Neuromediator, Reuptake inhibitor, Serotonin, Depression, Mood disorder, Panic, Obsessive compulsive disorder, Anxiety disorder, Multicenter study, Epidemiology, Belgium, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0227458
Code Inist : 002B02B02. Création : 09/06/1995.