Relation of exposure to airway irritants in infancy to prevalence of bronchial hyper-responsiveness in schoolchildren.
To find out whether exposure to sulphur dioxide during infancy is related to the prevalence of bronchial hyperresponsiveness (BHR), we studied schoolchildren (aged 7-13 years) from two areas of Norway-a valley containing a sulphur-dioxide-emitting aluminium smelter and a similar but non-industrialised valley.
Bronchial responsiveness was assessed in 529 of the 620 participants.
The median exposures to sulphur dioxide and fluoride were 37.1 mug/m3 and 4.4 mug/m3 at ages 0.12 months and 37.9 mug/m3 and 4.4 mug/m3 at 13-36 months.
The risk of BHR increased with exposure to sulphur dioxide and fluoride at these ages ; the odds ratio for a 10 mug/m3 increase in sulphur dioxide exposure at 0-12 months was 1.62 (95% CI 1.11-2.35) and that for a 1 mug/m3 increase in fluoride exposure was 1.35 (1.07-1.70) at 0.12 months and 1.38 (1.05-1.82) at 13-36 months.
Exposure to these low concentrations of airway irritants during early childhood is associated with an increased prevalence of BHR in schoolchildren.
Mots-clés Pascal : Facteur risque, Homme, Enfant, Hyperréactivité, Bronche, Soufre dioxyde, Prévalence, Exposition, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Risk factor, Human, Child, Hyperreactivity, Bronchus, Sulfur dioxide, Prevalence, Exposure, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0226332
Code Inist : 002B30A02A. Création : 09/06/1995.