Results of epidemiologic studies suggest that there is limited evidence for the association between cigarette smoking and risk of colorectal cancer.
Cigarette smoking has been shown to increase the risk of colorectal adenomatous polyps, which are recognized as precursors of colorectal cancer, while few studies have examined the association between alcohol consumption and the development of adenomatous polyps.
We examined the association between cigarette smoking, alcohol consumption, and the presence of colorectal adenomatous polyps.
Analyses were based on data from a case-control study of dietary and other lifestyle factors for colorectal adenomatous polyps.
We assessed the risk of adenomatous polyps associated with total number of years of smoking, number of cigarettes smoked per day, and pack-years of smoking for past and current smokers separately.
We also assessed the joint association between cigarette smoking and alcohol consumption on the risk of adenomatous polyps.
Current smokers who smoked more than 20 pack-years were at significantly higher risk of adenomatous polyps compared with never smokers (odds ratio [OR]=2.56 ; 95% confidence interval [CI]=1.28-5.14).
Past smokers also had an increased risk of having adenomatous polyps, but no clear trend was observed for pack-years of smoking.
Mots-clés Pascal : Polype adénomateux, Côlon, Rectum, Epidémiologie, Homme, Facteur risque, Ethanol, Consommation alimentaire, Tabagisme, Lésion précancéreuse, Appareil digestif pathologie, Intestin pathologie, Tumeur
Mots-clés Pascal anglais : Adenomatous polyp, Colon, Rectum, Epidemiology, Human, Risk factor, Ethanol, Food intake, Tobacco smoking, Premalignant lesion, Digestive diseases, Intestinal disease, Tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0224951
Code Inist : 002B13B01. Création : 09/06/1995.