Methylation of DNA, which may have a role in the regulation of gene expression, depends on dietary folate and methionine.
Because aberrant DNA methvlation may contribute to the initiation or progression of colon cancer, we hypothesized that deficient intakes of folate or methionine and high consumption of alcohol, an antagonist of methyl-group metabolism, increase risk of colon neoplasia.
Previously, a high-alcohol and low-methionine-low-folate (methyl-dehcient) diet was shown to be related to a higher risk of colon adenomas, precursors of cancer.
Our goal was to determine if ingestion of a high-alcohol, methyl-deficient diet is related directly to risk of colon cancer.
We assessed dietary intake for a 1-year period for a cohort of 47 931 U.S. male health professionals, 40-75 years old and free of diagnosed cancer in 1986.
We assessed diet by using a validated, semiquantitative food-frequency questionnaire.
During 6 years of follow-up, we documented 205 new cases of colon cancer in this cohort.
Current alcohol intake was directly related to risk of colon cancer (multivariate relative risk [RR]=2.07 ; 95% confidence interval [CI]=1.29-3.32, for>2 drinks versus ¾0.25 drink daily ; P trend=005), and past drinkers were also at higher risk (RR=1.95 ; 95% CI=1.22-3.10).
Individually, folate and methionine intakes were weakly inversely associated with risk of colon cancer.
Mots-clés Pascal : Tumeur maligne, Côlon, Epidémiologie, Ethanol, Méthionine, Folique acide, Régime alimentaire, Facteur risque, Etude cohorte, Homme, Mâle, Appareil digestif pathologie, Intestin pathologie
Mots-clés Pascal anglais : Malignant tumor, Colon, Epidemiology, Ethanol, Methionine, Folic acid, Diet, Risk factor, Cohort study, Human, Male, Digestive diseases, Intestinal disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0224950
Code Inist : 002B13B01. Création : 09/06/1995.