It has been suggested that aspects of lactose consumption and metabolism favoring a relatively high tissue level of galactose-1 - phosphate may predispose women to ovarian cancer.
The authors sought to examine this hypothesis in a study of 108 18-to 74-year-old Caucasian residents of a three-county area of western Washington who were diagnosed with stage I ovarian cancer during 1989-1991, and 108 age-and race-matched controls.
Lactose and galactose intake, measured using a food frequency questionnaire, had been hypothesized to increase risk, but were somewhat lower among the cases than among the controls (75th percentile of lactose intake vs. 25th : odds ratio (OR)=0.80,95% confidence interval (CI) 0.52-1.2 ; of galactose intake : OR=0.71,95% CI 0.48-1.1).
Intestinal lactase activity, also hypothesized to have a positive relation with ovarian cancer occurrence, was measured with an oral lactose challenge followed by determination of urinary galactose ; no evidence that it was related to the disease was found (75th percentile of excreted galactose vs. 25th : OR=0.87,95% CI 0.62-1.2).
Galactose-1-phosphate uridyltransferase (transferase), the enzyme responsible for the metabolism of galactose-1-phosphate, was measured in erythrocytes ; no deficit in cases was observed (75th percentile of transferase activity vs. 25th : OR=1.3,95% CI 0.80-2.1).
Mots-clés Pascal : Epithélioma, Ovaire, Epidémiologie, Lactose, Galactose, Métabolisme, Homme, Femelle, Lactase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Transferases, Washington, Etats Unis, Amérique du Nord, Amérique, Tumeur maligne, Ovaire pathologie, Appareil génital femelle pathologie
Mots-clés Pascal anglais : Carcinoma, Ovary, Epidemiology, Lactose, Galactose, Metabolism, Human, Female, Lactase, O-Glycosidases, Glycosidases, Hydrolases, Enzyme, Transferases, Washington, United States, North America, America, Malignant tumor, Ovarian diseases, Female genital diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0221721
Code Inist : 002B20C02. Création : 09/06/1995.