Resistance of Mycobacterium tuberculosis (M. tb) strains is an increasing problem worldwide.
Since no public health data are available for urban populations in Germany, we investigated resistance in our hospitalized patients (n=1,011) over the last 7 yrs.
We therefore evaluated clinical data and results of susceptibility tests (breakpoint technique/proportion method) for isoniazid, streptomycin, rifampin, pyramide, protionamide and ethambutol.
Since 1987, there has been a relatively constant rate of 5.9% (3.9% - 7.8%) for single-drug resistance (SDR), but an increasing rate of multidrug-resistant (MDR) strains (=2 first-line drugs) from 1.7% in 1987 to 5.8% in 1993.
Sixty nine percent of patients with MDR strains showed resistance to two drugs, and 31% to three or more drugs.
Risk factors for SDR and MDR tuberculosis revealed previous therapy (odds ratio (OR) (95% confidence interval (95% CI)) ; SDR 2.2 (1.7-4.0) ; MDR 4.5 (23-8.8)) ; and foreign-born status (SDR 2.2 (1.3-3.6) ; MDR 3.5 (1.8-6.8)) to be the most important factors associated with resistance.
Both primary and acquired resistance were higher in foreign-born than in German-born patients.
We conclude that there was a considerable increase in multidrug-resistant tuberculosis in our hospital from 1987 to 1993.
Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Poumon, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, Antituberculeux, Résistance traitement, Traitement, Complication, Epidémiologie, Homme, Berlin, Allemagne, Europe, Appareil respiratoire pathologie, Poumon pathologie, Chimiothérapie
Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Lung, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, Antituberculous agent, Negative therapeutic reaction, Treatment, Complication, Epidemiology, Human, Berlin, Germany, Europe, Respiratory disease, Lung disease, Chemotherapy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0221000
Code Inist : 002B02S02. Création : 09/06/1995.