To determine how maternal exposure to environmental tobacco smoke affects birthweight, maternal sera obtained from 3529 pregnant women around 27 weeks gestation were analyzed for cotinine, a metabolite of nicotine.
Based on cotinine levels, nonsmokers were divided into those exposed to environmental tobacco smoke (2-10 ng/mL) and those unexposed (<2 ng/mL), and smokers were divided into tertiles.
Compared with unexposed nonsmokers'infants, infants of exposed nonsmokers averaged 45 g less (P=28) after adjustment for confounders, and smokers'infants averaged 78,191, and 233 g less for the first, second, and third cotinine tertiles, respectively.
Birthweight decreased 1 g for every nanogram per milliliter of cotinine increase (P<. 001).
Mots-clés Pascal : Tabagisme, Tabagisme passif, Mère, Gestation, Toxicité, Poids naissance, Nourrisson, Homme, Cotinine, Epidémiologie, Californie, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Tobacco smoking, Passive smoking, Mother, Pregnancy, Toxicity, Birth weight, Infant, Human, Epidemiology, California, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0220411
Code Inist : 002B03E. Création : 09/06/1995.