The relationships of rate of weight gain and weight fluctuation to incidence of non-insulin-dependent diabetes mellitus (NIDDM) were examined in Pima Indians.
The 1,458 subjects were participants in a prospective study with examinations approximately every 2 years.
Rate of weight gain was defined as the slope of the regression line of weight with time for two or more consecutive examinations =2 years apart and weight fluctuation as the root-mean-square departure from this line for four examinations.
Among men, incidence of NIDDM was strongly and significantly related to rate of weight gain (e.g., age-adjusted incidence=56.7/1,000 person-years in those with weight gain =3 kg/year and 16.9/1,000 person-years for those losing weight [Ptrend<0.01]). In women, weight gain was significantly related to diabetes incidence only in those who were not initially overweight (body mass index<27.3 KG/M2).
In contrast to the relationship with weight gain, weight fluctuation was not associated with incidence of diabetes in either sex.
These findings suggest that weight control in overweight individuals may be a more effective strategy for prevention of NIDDM in men than in women, whereas prevention of obesity may prevent diabetes in both sexes.
Concern about a diabetogenic effect of weight fluctuation should not deter weight-control efforts.
Mots-clés Pascal : Diabète non insulinodépendant, Poids corporel, Prise poids, Obésité, Epidémiologie, Amérindien, Etats Unis, Homme, Pima, Amérique du Nord, Amérique, Endocrinopathie
Mots-clés Pascal anglais : Non insulin dependent diabetes, Body weight, Weight gain, Obesity, Epidemiology, Amerindian, United States, Human, North America, America, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0213314
Code Inist : 002B30A01A2. Création : 09/06/1995.