An investigation of visual evoked potentials was carried out in two groups of subjects ; 49 workers employed in a printing-press where toluene has been used exclusively as an organic solvent for the last 30 years, and 59 workers not occupationally exposed to any known neurotoxic substances.
The average length of work service in the printing-press was 21.4 years.
The level of exposure was assessed by determination of the concentration of toluene in peripheral blood, the concentration of hippuric acid and ortho-cresol in urine in subgroups of subjects chosen at random from both groups.
N75, P100 and N145 waves of the pattern reversal visual evoked potentials were analyzed.
In the group of exposed subjects, significantly greater amplitudes were found in all waves, with significantly longer latency of the P100 wave.
Mots-clés Pascal : Toluène, Solvant organique, Toxicité, Exposition professionnelle, Homme, Chronique, Potentiel évoqué visuel, Electrophysiologie, Système nerveux central, Système nerveux pathologie, Médecine travail
Mots-clés Pascal anglais : Toluene, Organic solvent, Toxicity, Occupational exposure, Human, Chronic, Visual evoked potential, Electrophysiology, Central nervous system, Nervous system diseases, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0211287
Code Inist : 002B03L04. Création : 09/06/1995.