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  1. Evidence of serological cross-reactivities with human immunodeficiency virus types 1 and 2 and human T-lymphotrophic virus types I and II in sera of pregnant women in Ibadan, Nigeria.

    Article - En anglais

    Background

    Our previous studies have indicated that the human immunodeficiency virus (HIV) and human T-lymphotropic virus (HTLV) groups of retroviruses are endemic among various populations in Nigeria.

    These viruses are antigenically distinct and antibodies to HIV and HTLV do not cross-react, so we studied the prevalence of HIV-1, HIV-2, HTLV-I and HTLV-II antibodies in sera of pregnant women attending an antenatal clinic in Ibadan, Nigeria.

    Methods

    In all, 364 sera were screened using three different enzyme immunoassays, including those that distinguished HIV-1 antibodies from HIV-2, and HTLV-I antibodies from HTLV-II.

    All repeatedly reactive sera were confirmed by Western blots and synthetic peptide assays for the respective viruses.

    Results

    Overall, 71 sera (19.5%) had antibodies to HIV, HTLV or both groups of retroviruses.

    Most (95.8%) of the reactive samples were from women 20-29 years old.

    Two of five sera from individuals<20 years old reacted for HIV antibodies while one serum from a 40 year old woman was reactive for HTLV-I antibodies.

    Of the 71 reactive sera, 29 (8%) had antibodies to HIV (HIV-1=14, HIV-2=9, HIV-1/2=6) and 42 samples (11.5%) showed antibodies to HTLV (HTLV-I=20, HTLV-II=14, HTLV-I/II=8).

    Seven of 71 seropositive samples (9.8%) reacted for both HIV and HTLV antibodies in various combinations, including one serum that showed antibody reactivities to all four retroviruses (i.e. HIV-1, HIV-2, HTLV-I and HTLV-II).

    Conclusions.

    Mots-clés Pascal : Virus HIV1, Virus immunodéficience humaine, Lentivirinae, Retroviridae, Virus, Virus HIV2, Virus HTLV2, Virus HTLV1, Sérologie, Prévalence, Epidémiologie, Homme, Femelle, SIDA, Virose, Infection, Gestation, Réaction croisée, Nigéria, Afrique, Immunopathologie, Immunodéficit

    Mots-clés Pascal anglais : HIV-1 virus, Human immunodeficiency virus, Lentivirinae, Retroviridae, Virus, HIV-2 virus, HTLV-II virus, HTLV-I virus, Serology, Prevalence, Epidemiology, Human, Female, AIDS, Viral disease, Infection, Pregnancy, Cross reaction, Nigeria, Africa, Immunopathology, Immune deficiency

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0209628

    Code Inist : 002B05C02J. Création : 09/06/1995.