Circumstantial evidence links endogenous estrogens to increased risk of breast cancer in women, but direct epidemiologic support is limited.
In particular, only a few small prospective studies have addressed this issue.
Our purpose was to assess breast cancer risk in relation to circulating levels of the two major endogenous estrogens, estrone and estradiol, measured before the clinical onset of the disease.
The association between serum levels of estrogens and the risk of breast cancer was examined in a prospective cohort study of 14 291 New York City women, 35-65 years of age, who received screening for breast cancer at the time of blood sampling and who had not been diagnosed with breast cancer.
During the first 5 1/2 years of study, we identified 130 breast cancers among the postmenopausal group (7063 women, 35 509 person-years).
The case subjects and twice as many postmenopausal control subjects were included in a case-control study nested within the cohort.
Biochemical analyses for percent free estradiol, percent estradiol bound to sex hormone-binding globulin (SHBG), total estradiol, estrone, and follicle-stimulating hormone were performed on sera that had been kept at - 80oC since sampling.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Facteur risque, Epidémiologie, Homme, Femelle, Postménopause, Oestrone, Oestradiol, Endogène, Forme liée, Glande mammaire pathologie, Oestrogène, Hormone stéroïde sexuelle, Hormone ovarienne
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Risk factor, Epidemiology, Human, Female, Postmenopause, Estrone, Estradiol, Endogenous, Bound form, Mammary gland diseases, Estrogen, Sex steroid hormone, Ovarian hormone
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0208937
Code Inist : 002B20E02. Création : 09/06/1995.