The role of genetic and shared environmental influences in the assication of alcohol with mortality was studied by using the National Academy of Sciences-National Research Council World War II-veteran male twin registry.
An epidemiologic questionnaire administered from 1967 through 1969 permitted identification of twin pairs discordant for alcohol consumption.
The subsequent 24 years of mortality follow-up yielded data on time and cause of death.
Analyzing the first or only death in drinking-discordant pairs, we observed 27 deaths in abstainer twins and 14 deaths in their light-to moderate-drinker cotwins (relative risk [RR]=1.93).
Excess mortality in twin abstainers was also indicated for deaths from cardiovasculr diseases (RR=2.0) and other cuases of death excluding cancers (RR=3.2).
The protective effect, however, of light to moderate drinking did not persist in twins who were smokers at baseline.
Mots-clés Pascal : Alcoolisme, Mortalité, Jumeau, Homme, Déterminisme génétique, Epidémiologie, Facteur risque, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Alcoholism, Mortality, Twin, Human, Genetic inheritance, Epidemiology, Risk factor, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0208929
Code Inist : 002B03F. Création : 09/06/1995.