Adenocarcinoma of the esophagus : role of obesity and diet.
In the United States, the incidence of adenocarcinoma of the esophagus, including the esophagogastric junction, has been increasing rapidly over the past two decades.
Except for an association with Barrett's esophagus, little is known about the etiology of these cancers.
Our purpose was to investigate dietary and nutritional risk factors for adenocarcinoma of the esophagus.
A population-based, case-control interview study of 174 white men with adenocarcinoma of the esophagus and 750 control subjects living in three areas of the United States was conducted during 1986 through 1989.
Risk was significantly elevated for subjects in the heaviest quartile compared with the lightest quartile of body mass index (odds ratio [OR]=3.1 ; 95% confidence interval [CI]=1.8-5.3).
No significant associations were seen with total calories from food, number of meals eaten per day, level of fat intake, or consumption of coffee and tea.
Risks were highest for those consuming the least amount of vegetables, with some evidence of a dose response for the subcategories of cruciferous vegetables (P for trend<. 001) and vegetables consumed raw (P for trend=10).
Mots-clés Pascal : Epithélioma glandulaire, Oesophage, Homme, Facteur risque, Epidémiologie, Obésité, Régime alimentaire, Etude statistique, Etats Unis, Amérique du Nord, Amérique, Etat nutritionnel, Appareil digestif pathologie, Oesophage pathologie, Tumeur maligne, Trouble nutrition
Mots-clés Pascal anglais : Adenocarcinoma, Esophagus, Human, Risk factor, Epidemiology, Obesity, Diet, Statistical study, United States, North America, America, Nutritional status, Digestive diseases, Esophageal disease, Malignant tumor, Nutrition disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0208528
Code Inist : 002B13A01. Création : 09/06/1995.