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  1. Occupation, smoking and demographic factors, and renal cell carcinoma in Germany.

    Article - En anglais

    Background

    The role of occupational exposure in the aetiology of renal cell cancer is still not clear.

    In a population-based, case-control study we investigated occupational and smoking history as well as place of residence, marital and socioeconomic status.

    Method

    In a case-control study in Germany, 277 adult cases with incident renal cell cancer and 266 controls frequency-matched to the cases for age and gender have been interviewed.

    The data were analysed by standard methods using unconditional logistic regression models, to estimate the relative risk (RR) and the corresponding 95% confidence interval (95% Cl).

    Results

    Socioeconomic status was inversely associated (RR=0.61,95% Cl : 0.3-1.2 for highest category) with the risk for renal cell cancer.

    Heavy smoking gave an increased, but not significant RR in men and women for ex-smokers and current smokers.

    Employment in metal-related industries (RR=1.63,95% Cl : 1.1-2.5) was also identified as a risk factor.

    Additionally, we found an elevated risk associated with exposure to perchloroethylene and tetrachlorocarbonate (RR=2.52,95% Cl : 1.2-5.2) but no time trend could be observed.

    No associations were found for other occupational exposures, such as working in the chemical industry, transportation or farming nor for exposure to pesticides.

    Conclusions

    The results of our study lead to the suggestion that smoking, occupation and demographic factors probably play a minor role in the aetiology of renal cell cancer.

    Mots-clés Pascal : Epithélioma, Rein, Epidémiologie, Allemagne, Europe, Tabagisme, Activité professionnelle, Statut socioéconomique, Composé chimique, Homme, Tumeur maligne, Rein pathologie, Appareil urinaire pathologie

    Mots-clés Pascal anglais : Carcinoma, Kidney, Epidemiology, Germany, Europe, Tobacco smoking, Professional activity, Socioeconomic status, Chemical compound, Human, Malignant tumor, Renal disease, Urinary system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0208177

    Code Inist : 002B14D01. Création : 09/06/1995.