Randomised trial of lipid lowering dietary advice in general practice : the effects of serum lipids, lipoproteins, and antioxidants.
To detemrine the relative efficacy in general practice of dietary advice given by a dietitian, a practice nurse, or a diet leaflet alone in reducing total and low density lipoprotein cholesterol concentration.
Design-Randomised six month parallel trial
Setting-A general practice in Oxfordshire.
Subjects-2004 subjects aged 35-64 years were screened for hypercholesterolaemia ; 163 men and 146 women with a repeat total cholesterol concentration of 6.0-8.5 mmol/l entered the trial.
Interventions-Individual advice provided by a dietitian using a diet history, a practice nurse using a structured food frequency questionnaire, or a detailed diet leaflet sent by post.
All three groups were advised to limit the energy provided by fat to 30% or less and to increase carbohydrate and dietary fibre.
Main outcome measures-Concentrations of total cholesterol and low density and bigh density lipoprotein cholesterol after six months ; antioxidant concentration and body mass index.
No significant differences were found at the end of the trial between groups in mean concentrations of lipids, lipoproteins, and antioxidants or body mass index.
After data were pooled from the three groups, the mean total cholesterol concentration fell by 1.9% (0.13 mmol/l, 95% confidence interval 0.06 to 0.22, P<0.001) to 7.00 mmol/l, and low density lipoprotein cholesterol also fell.
The total carotenoid concentration increased by 53 nmol/l (95% confidence interval 3.0 to 103, P=0.039).
Mots-clés Pascal : Education nutritionnelle, Soin santé primaire, Diminution, Lipide, Régime alimentaire, Effet biologique, Lipoprotéine, Antioxydant, Sérum, Cholestérol, Poids corporel, Homme, Métabolisme pathologie
Mots-clés Pascal anglais : Nutrition education, Primary health care, Decrease, Lipids, Diet, Biological effect, Lipoprotein, Antioxidant, Serum, Cholesterol, Body weight, Human, Metabolic diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0207482
Code Inist : 002B22A. Création : 09/06/1995.