To determine the risk factors for noninsulin dependent diabetes in a cohort representative of middle aged British men.
Subjects and setting-7735 men aged 40-59, drawn from one group practice in each of 24 towns in Britain.
Known and probable cases of diabetes at screening (n=158) were excluded.
Main outcome measures-Non-insulin dependent diabetes (doctor diagnosed) over a mean follow up period of 12-8 years.
There were 194 new cases of non-insulin dependent diabetes.
Body mass index was the dominant risk factor for diabetes, with an age adiusted relative risk (upper fifth to lower fifth) of 11.6 ; 95% confidence interval 5.4 to 16.8. Men engaged in moderate levels of physical activity had a substantially reduced risk of diabetes, relative to the physically inactive men, after adjustment for age and body mass index (0.4 ; 0.2 to 0.7), an association which persisted in full multivariate analysis.
A nonlinear relation between alcohol intake and diabetes was observed, with the lowest risk among moderate drinkers (16-42 units/week) relative to the baseline group of occasional drinkers (0.6 ; 0.4 to 1.0).
Additional significant predictors of diabetes in multivariate analysis included serum triglyceride concentration, high density lipoprotein cholesterol concentration (inverse association), heart rate, uric acid concentration, and prevalent coronary heart disease.
Mots-clés Pascal : Diabète non insulinodépendant, Facteur risque, Poids corporel, Exercice physique, Boisson alcoolisée, Triglycéride, Cholestérol, Cardiopathie coronaire, Homme, Age mûr, Endocrinopathie
Mots-clés Pascal anglais : Non insulin dependent diabetes, Risk factor, Body weight, Physical exercise, Alcoholic beverage, Triglyceride, Cholesterol, Coronary heart disease, Human, Middle age, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0207480
Code Inist : 002B21E01A. Création : 09/06/1995.