logo BDSP

Base documentaire


  1. Incidence and outcome of pauci-immune necrotizing and crescentic glomerulonephritis in adults.

    Article - En anglais

    During a seven-year period (1986-1992) 719 adults (age>16 years) underwent diagnostic renal biopsy in Stockholm (adult population 1.2 million).

    Seventy-one (10%) new cases of pauci-immune necrotizing and crescentic glomerulonephritis (NCGN) with or without systemic vasculitis were found : 39 females and 32 males (median age 67, range 20-84 years).

    The mean yearly incidence for the whole period was 0.8/100,000 population.

    The yearly incidence doubled from 0.6 before to 1.2/100,000 population after 1990.

    The incidence was highest among those>65 years of age.

    Age-correlated incidences for this ape group increased from 1.4 before to 3.9/100,000 after 1990.

    Anti-neutrophil cytoplasmic antibodies (ANCAs) tested in 60, showed antibodies against proteinase 3 (PR3) in 29 patients, against myeloperoxidase (MPO) in 26 and none in five patients.

    Mortality was highest in the early stapes of the di sease.

    From a total of 11 patients, 7 (15%) died within 2.5 months of diagnosis.

    Forty-six out of all 71 patients with NCGN belonged to the catchment area of our clinic and were studied in more detail.

    Twenty-six had microscopic polyangiitis (ANCAs were analyzed in 24, of these 16 had anti-MPO, 6 anti-PR3,2 had none), 13 had Wegener's granulomatosis (ANCAs were analyzed in all, of these 12 had anti-PR3,1 anti-MPO) and seven had disease limited to the kidneys.

    (ANCAs were analyzed in 6,5 had anti-MPO, one was negative).

    Mots-clés Pascal : Néphropathie glomérulaire, Vascularite nécrosante, Adulte, Homme, Incidence, Symptomatologie, Pronostic, Complication, Epidémiologie, Suède, Europe, Appareil urinaire pathologie, Rein pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Maladie système, Anticorps anticytoplasme polynucléaire neutrophile

    Mots-clés Pascal anglais : Glomerulonephritis, Necrotizing vasculitis, Adult, Human, Incidence, Symptomatology, Prognosis, Complication, Epidemiology, Sweden, Europe, Urinary system disease, Renal disease, Cardiovascular disease, Vascular disease, Systemic disease, Antineutrophil cytoplasmic antibody

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0203408

    Code Inist : 002B14A01. Création : 09/06/1995.