1 Sodium monofluoroacetate (1080), a vertebrate pesticide used in New Zealand, was administered orally to rabbits at two dose levels (sub-lethal and lethal) to determine how long 1080 would persist in plasma, liver, kidney, and muscle so that the risk of consumption of meat from lethally or sub-lethally poisoned rabbits by non-target species could be assessed. 2 The plasma elimination half-life in rabbits receiving a sub-lethal dose was 1.1 h. Retention of 1080 in tissue was greater in rabbits dosed with a lethal dose than in those that received a sub-lethal dose.
Irrespective of the dose level, concentration of 1080 in muscle, kidney, and liver was substantially lower than in the plasma. 3 Poisoning of dogs is possible because of their extreme susceptibility to 1080.
Poisoning of birds is less likely.
The risk of secondary poisoning is reduced as the concentration of 1080 declines in putrefying carcasses.
Mots-clés Pascal : Pesticide, Rodenticide, Toxicité, Voie orale, Animal, Lapin, Lagomorpha, Mammalia, Vertebrata, Toxicocinétique, Ecotoxicologie, Animal sauvage, Homme, Nouvelle Zélande, Océanie, Fluor Composé organique, Sodium acétate(fluoro), Composé 1080
Mots-clés Pascal anglais : Pesticides, Rodenticide, Toxicity, Oral administration, Animal, Rabbit, Lagomorpha, Mammalia, Vertebrata, Toxicokinetics, Ecotoxicology, Wild animal, Human, New Zealand, Oceania, Fluorine Organic compounds
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0202497
Code Inist : 002B03G. Création : 09/06/1995.