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  1. Inheritance and testicular cancer.

    Article - En anglais

    Statistical analysis of published data on the age of onset of germ cell tumours of the testis and of the prevalence of bilateral disease in familial and general cases suggest the following : 1. Patients with bilateral disease carry the same genetic predisposition as familial cases. 2. Males with the hereditary predisposition develop none, unilateral or bilateral tumours in the proportions 55%, 38% and 7% respectively. 3. One-third of all testis cancer patients are genetically predisposed to the disease. 4. The 2.2% risk to brothers of cases as reported elsewhere can be accounted for by the homozygous (recessive) inheritance of a single predisposing gene.

    Mots-clés Pascal : Tumeur germinale, Testicule, Déterminisme génétique, Facteur risque, Epidémiologie, Fratrie, Père, Royaume Uni, Europe, Homme, Tumeur maligne, Testicule pathologie, Appareil génital mâle pathologie, Maladie héréditaire

    Mots-clés Pascal anglais : Germ cell tumor, Testicle, Genetic inheritance, Risk factor, Epidemiology, Sibling, Father, United Kingdom, Europe, Human, Malignant tumor, Testicular diseases, Male genital diseases, Genetic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0200544

    Code Inist : 002B20B02. Création : 09/06/1995.