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  1. Cancer incidence in men with Klinefelter syndrome.

    Article - En anglais

    Many case reports have suggested an association between Klinefelter syndrome (KS) and cancer, but studies of the cancer incidence in larger groups of men with KS are lacking.

    A cohort of 696 men with KS was established from the Danish Cytogenetic Register.

    Information on the cancer incidence in the cohort was obtained from the Danish Cancer Registry and compared with the expected number calculated from the age, period and site specific cancer rates for Danish men.

    A total of 39 neoplasms were diagnosed (relative risk=1.1).

    Four mediastinal tumours were observed (relative risk=67) ; all four were malignant germ cell tumours.

    No cases of breast cancer or testis cancer were observed.

    One case of prostate cancer occurred within a previously irradiated field.

    No excess of leukaemia or lymphoma was found.

    An increased risk of cancer occurred in the age group 15-30 years (relative risk=2.7).

    All six tumours in this group were germ cell tumours or sarcomas.

    The overall cancer incidence is not increased and no routine cancer screening seems to be justified.

    A considerably elevated risk of mediastinal germ cell tumours occurs in the period from early adolescence until the age of 30.

    Mots-clés Pascal : Klinefelter syndrome, Association, Tumeur maligne, Lymphome, Leucémie, Incidence, Epidémiologie, Danemark, Europe, Mâle, Homme, Appareil génital mâle pathologie, Chromosome X surnuméraire, Aneuploïdie, Aberration chromosomique, Hypogonadisme, Endocrinopathie, Malformation, Hémopathie maligne, Lymphoprolifératif syndrome, Anomalie différenciation sexuelle

    Mots-clés Pascal anglais : Klinefelter syndrome, Association, Malignant tumor, Lymphoma, Leukemia, Incidence, Epidemiology, Denmark, Europe, Male, Human, Male genital diseases, Supernumerary X chromosome, Aneuploidy, Chromosomal aberration, Hypogonadism, Endocrinopathy, Malformation, Malignant hemopathy, Lymphoproliferative syndrome

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0200543

    Code Inist : 002B04B. Création : 09/06/1995.