Individual susceptibility and prevention of occupational diseases : scientific and ethical issues.
Genetic testing of employees is controversial ; objections have been raised with regard to privacy, right to work, and the relevance of the tests.
A study is being conducted on « the ethical, social, and scientific problems related to the application of genetic screening and genetic monitoring for employees in the context of a European approach to health and safety at work. » A conceptual model is proposed of the complex interactions between exposure, acquired and inherited susceptibility, and risk for disease.
The validity of tests for determining genotype and phenotype and their relevance for disease must be evaluated critically to provide an objective basis for ethiral discussions.
The acceptability of such tests is related to a number of issues, which are identified and discussed.
Mots-clés Pascal : Exposition professionnelle, Maladie professionnelle, Homme, Sensibilité résistance, Comparaison interindividuelle, Facteur risque, Prévention, Surveillance biologique, Ethique, Déterminisme génétique, Héréditaire, Dépistage, Phénotype acétylateur
Mots-clés Pascal anglais : Occupational exposure, Occupational disease, Human, Sensitivity resistance, Interindividual comparison, Risk factor, Prevention, Biological monitoring, Ethics, Genetic inheritance, Hereditary, Medical screening, Acetylator phenotype
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0192482
Code Inist : 002B30B04. Création : 09/06/1995.