1,3-Butadiene (BD) is a carcinogen in both rats and mice with mice being substantially more sensitive than rats.
It is not known if BD poses a carcinogenic risk for humans.
Findings from exposure assessment studies indicate that potential industrial exposure to BD in monomer, polymer, and end-user industries is typically<2 p.p.m. Epidemiologic studies of persons occupationally exposed to BD are inconclusive.
In vitro metabolism of BD in rats, mice and human tissues indicate that there are significant quantitative species differences in the metabolic activation of BD to butadiene monoepoxide (BMO) and butadiene diepoxide (BDE) and the detoxication of BMO.
Activation/detoxication ratios calculated using in vitro kinetic constants reveal that ratios in mice were 12-fold greater than rats and humans.
In rats and mice exposed to BD, concentrations of BMO in blood and tissues of mice were up to 14-fold higher than in rats and BDE was only detected in mice thereby providing a strong argument for why mice are highly sensitive to BD carcinogenicity.
The fact that human tissues do not appear to metabolize BMO to BDE to any significant extent suggest that humans may not be sensitive to BD carcinogenicity.
Mots-clés Pascal : Carcinogène, Epidémiologie, Facteur risque, Métabolisme, Pharmacocinétique, Animal, Homme, Article synthèse, Butadiène, Approche mécaniste, Exposition professionnelle, Environnement
Mots-clés Pascal anglais : Carcinogen, Epidemiology, Risk factor, Metabolism, Pharmacokinetics, Animal, Human, Review, Butadiene, Mechanistic approach, Occupational exposure, Environment
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0191602
Code Inist : 002B04E02. Création : 09/06/1995.