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  1. Weight in infancy and prevalence of coronary heart disease in adult life.

    Article - En anglais


    To determine whether low birth weight and low weight at 1 year are followed by an increased prevalence of coronary heart disease in adult life.

    Design-A follow up study of men born during 1920-30 whose birth weights and weights at 1 year were recorded.

    Setting-Hertfordshire, England, Subjects-290 men born and still living in East Hertfordshire.

    Main outcome measure-The prevalence of coronary heart disease, defined by the Rose/WHO chest pain questionnaire, standard electrocardiographic criteria, or history of coronary artery angioplasty or graft surgery.


    42 (14%) men had coronary heart disease.

    Their mean birth weight, 7.9 1b (3600 g), was the same as that of the other men.

    Their mean weight at 1 year, 21.8 lb (9.9 kg), was 1 lb (454 g) lower (95% confidence interval 0.1 to 1.8, P=0.02).

    Percentages of men with coronary heart disease fell from 27% in those who weighed 18 lb (8.2 kg) or less at 1 year to 9% in those who weighed more than 26 lb (11.8 kg) (P value for trend=0.03).

    This trend occurred in both smokers and non-smokers and within each social class.

    Conclusion-These findings add to the evidence that coronary heart disease is « programmed » during early growth.

    Mots-clés Pascal : Appareil circulatoire pathologie, Cardiopathie coronaire, Facteur risque, Homme, Nourrisson, Adulte, Etude comparative, Poids, Naissance, Faible, Tabagisme, Classe sociale, Angleterre, Grande Bretagne, Royaume Uni, Europe

    Mots-clés Pascal anglais : Cardiovascular disease, Coronary heart disease, Risk factor, Human, Infant, Adult, Comparative study, Weight, Birth, Low, Tobacco smoking, Social class, England, Great Britain, United Kingdom, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0191220

    Code Inist : 002B12A03. Création : 09/06/1995.