To determine whether low birth weight and low weight at 1 year are followed by an increased prevalence of coronary heart disease in adult life.
Design-A follow up study of men born during 1920-30 whose birth weights and weights at 1 year were recorded.
Setting-Hertfordshire, England, Subjects-290 men born and still living in East Hertfordshire.
Main outcome measure-The prevalence of coronary heart disease, defined by the Rose/WHO chest pain questionnaire, standard electrocardiographic criteria, or history of coronary artery angioplasty or graft surgery.
42 (14%) men had coronary heart disease.
Their mean birth weight, 7.9 1b (3600 g), was the same as that of the other men.
Their mean weight at 1 year, 21.8 lb (9.9 kg), was 1 lb (454 g) lower (95% confidence interval 0.1 to 1.8, P=0.02).
Percentages of men with coronary heart disease fell from 27% in those who weighed 18 lb (8.2 kg) or less at 1 year to 9% in those who weighed more than 26 lb (11.8 kg) (P value for trend=0.03).
This trend occurred in both smokers and non-smokers and within each social class.
Conclusion-These findings add to the evidence that coronary heart disease is « programmed » during early growth.
Mots-clés Pascal : Appareil circulatoire pathologie, Cardiopathie coronaire, Facteur risque, Homme, Nourrisson, Adulte, Etude comparative, Poids, Naissance, Faible, Tabagisme, Classe sociale, Angleterre, Grande Bretagne, Royaume Uni, Europe
Mots-clés Pascal anglais : Cardiovascular disease, Coronary heart disease, Risk factor, Human, Infant, Adult, Comparative study, Weight, Birth, Low, Tobacco smoking, Social class, England, Great Britain, United Kingdom, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0191220
Code Inist : 002B12A03. Création : 09/06/1995.