A stratified sample of 83 children living in Uniontown, Pennsylvania, reported twice daily peak expiratory flow rate (PEFR) measurements on 3,582 child-days during the summer of 1990.
Upon arising and before retiring, each child recorded the time, three PEFR measurements, and the presence of cold, cough, or wheeze symptoms.
Ambient air pollution, including particle-strong acidity, was measured separately during the day (8 a.m. to 8 p.m.) and at night.
Each child's maximum PEFR for each session was expressed as the deviation from his or her mean PEFR over the study and adjusted to a standard of 300 liters/minute.
The session-specific average deviation was then calculated across all of the children.
A second-order autoregressive model for PEFR was developed, which included a separate intercept for evening measurements, trend, temperature, and 12-hour average air pollutant concentration weighted by the number of hours each child spent outdoors during the previous 12-hour period.
The results are expressed in terms of the interquartile range for each pollutant.
A 12-hour exposure to a 125-nmol/m3 increment in particle-strong acidity was associated with a - 2.5 liters/minute deviation in the group mean PEFR (95% confidence interval (CI) 4.2 to - 0.8) and with increased cough incidence (odds ratio (OR)=1.6,95% CI 1.1 to 2.4).
A 30-ppb increment in ozone for 12 hours was associated with a similar deviation in PEFR levels (-2.8,95% CI-6.7 to 1.1).
Mots-clés Pascal : Appareil respiratoire pathologie, Fonction respiratoire, Débit expiratoire, Enfant, Homme, Epidémiologie, Pollution air, Toxicité, Pennsylvanie, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Respiratory disease, Lung function, Expiratory flow rate, Child, Human, Epidemiology, Air pollution, Toxicity, Pennsylvania, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0185987
Code Inist : 002B03M02. Création : 09/06/1995.