Effects of preconceptional irradiation on mortality and cancer incidence in the offspring of patients given injections of thorotrast.
Findings from a British case-control study suggest that a preconceptional paternal external radiation dose of more than 100 mSv (10 rem) is significantly related to risk for leukemia and non-Hodgkin's lymphoma in offspring.
The suggestion, however, has not been supported by experimental or other epidemiologic studies.
The purpose of this study was to investigate if preconceptional irradiation of males and females from internally deposited radionuclides affects mortality and risk of developing cancer in their offspring.
The offspring of 260 females (n=143) and 320 males (n=226) who lived longer than 1 year after receiving Thorotrast (a compound no longer in use) for cerebral arteriography were studied for mortality rate and the risk for developing cancer.
Thorotrast was used as a contrast medium containing a 20% colloidal solution of thorium dioxide-Th 232, an alpha particle-emitting radionuclide, which is retained lifelong in nearly all organs.
Mots-clés Pascal : Tumeur maligne, Hémopathie maligne, Enfant, Homme, Epidémiologie, Facteur risque, Irradiation alpha, Produit radioisotopique, Thorotrast, Traitement père, Traitement mère, Toxicité, Carcinogène, Tératogène, Gestation, Danemark, Europe, Irradiation ionisante
Mots-clés Pascal anglais : Malignant tumor, Malignant hemopathy, Child, Human, Epidemiology, Risk factor, Alpha irradiation, Radiopharmaceuticals, Paternal treatment, Maternal treatment, Toxicity, Carcinogen, Teratogen, Pregnancy, Denmark, Europe, Ionizing irradiation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0185443
Code Inist : 002B02U10. Création : 09/06/1995.