Familial clustering of breast and prostate cancers and risk of postmenopausal breast cancer.
Previous studies have suggested that cancers of the breast and prostate cluster in families and that the presence of both diseases in a family may be associated with increased risk of breast cancer.
Our purpose was to evaluate whether 1) prostate cancer aggregates in families with postmenopausal breast cancer, 2) families with cancers of the breast and prostate are the same ones as families with cancers of the breast and ovary, and 3) a family history of prostate cancer is associated with increased risk of postmenopausal breast cancer.
We analyzed data from a large prospective cohort study of Iowa women that were (at baseline) aged 55-69 years in 1986.
At the third follow-up survey in 1992, self-reported data on family history of breast, ovarian, and prostate cancers in parents and siblings were provided by 30 883 women.
Additional information was collected to ascertain whether the age-of-onset of breast cancer in mothers of sisters was before or after the age of 45 years.
Cancer occurrence was documented using the State Health Registry of Iowa.
History of protate cancer in their father or a brother was reported by 3384 (11.0%) of the women, and a total of 4090 women (13.2%) reported breast cancer in their mother or a sister.
A positive family history of both cancers was reported by 556 women, significantly (two-sided P<. 001) greater than the 457 women expected if the family histories were independent.
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Postménopause, Epidémiologie, Facteur risque, Pathogénie, Antécédent, Groupe familial, Prostate, Etude cohorte, Etats Unis, Amérique du Nord, Amérique, Homme, Femelle, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Postmenopause, Epidemiology, Risk factor, Pathogenesis, Antecedent, Family group, Prostate, Cohort study, United States, North America, America, Human, Female, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0185358
Code Inist : 002B20E02. Création : 09/06/1995.