The natural history of juvenile chronic arthritis : a population based cohort study. I : Onset and disease process.
To study the natural history and the disease process in a population based cohort of patients with juvenile chronic arthritis (JCA) who were in the process of being transferred from pediatric to adult rheumatology care.
From a prospective population based epidemiological study in southwestern Sweden the cohort of patients with JCA born from 1968 through 1972 were investigated after a median disease duration of 7.1 years.
The study cohort constituted of 124 patients with median age 17.7 years.
At followup 49.2% patients still required medication, 20.2% had inactive disease and 30.6% were in remission.
The highest risk of continuing disease activity was observed in patients with short disease duration (RR=9.0) or very long duration (RR=2.5) compared with those having medium long duration.
Girls were 5 times more likely than boys to have continuing disease activity.
Based on incidence data from the total population of the epidemiological study it can be estimated that an additional 100 patients with JCA, who were in remission in the beginning of the study, should be included in the present cohort.
Thus a total of 60% of the patients with JCA had disease in remission and 70% were rid of disease activity when reaching adulthood in a population based setting.
Mots-clés Pascal : Rhumatisme inflammatoire, Enfant, Homme, Epidémiologie, Prévalence, Symptomatologie, Evolutivité, Exploration radiologique, Pronostic, Etude cohorte, Etude longitudinale, Suède, Europe, Système ostéoarticulaire pathologie, Arthrite chronique juvénile
Mots-clés Pascal anglais : Inflammatory joint disease, Child, Human, Epidemiology, Prevalence, Symptomatology, Evolutivity, Radiologic investigation, Prognosis, Cohort study, Follow up study, Sweden, Europe, Diseases of the osteoarticular system, Juvenile rheumatoid arthritis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0182963
Code Inist : 002B15D. Création : 09/06/1995.