Interventions to avoid atherosclerosis might be more successful if launched early in life when eating and life-style patterns are formed, but dietary interventions have been limited by fears of diet-induced growth failure.
We investigated the effects of a diet low in saturated fat and cholesterol on serum lipid concentrations and growth in 1062 healthy 7-month-old infants in a randomised study.
Every 1-3 months, families in the intervention group received dietary advice aimed at adequate energy supply, with low fat intake (30-35% energy, polyunsaturated/monounsaturated/saturated fatty acid ratio 1/1/1, and cholesterol intake<200 mg daily).
Infants in control families consumed an unrestricted diet. 3-day food records were collected at ages 8 and 13 months.
Growth was carefully monitored.
Between 7 and 13 months serum cholesterol and non-high-density-lipoprotein cholesterol concentrations did not change significantly in the intervention group (mean change - 0.03 [SD 0.72] mmol/L and 0.01 [0.67] mmol/L) but increased substantially in the control group (0.24 [0.64] mmol/L and 0.23 [0.60] mmol/L ; p for difference in mean changes between groups<0.001).
Daily intakes of energy and saturated fat were lower in the intervention than in the control group at 13 months (4065  vs 4370  kJ, p=0.033, and 9.3 [3.5] vs 14.5 [4-8] g, p<0.001, respectively), and intake of polyunsaturated fat was higher (5.8 [2.2] vs 4.4 [1.4] g, p<0.001).
Mots-clés Pascal : Prévention, Homme, Nourrisson, Etude comparative, Régime alimentaire restrictif, Acide gras saturé, Cholestérol, Essai thérapeutique contrôlé, Randomisation, Finlande, Europe
Mots-clés Pascal anglais : Prevention, Human, Infant, Comparative study, Restricted diet, Saturated fatty acid, Cholesterol, Controlled therapeutic trial, Randomization, Finland, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0177135
Code Inist : 002B02A06. Création : 09/06/1995.