Prospective randomised trial in 1062 infants of diet low in saturated fat and cholesterol.
Interventions to avoid atherosclerosis might be more successful if launched early in life when eating and life-style patterns are formed, but dietary interventions have been limited by fears of diet-induced growth failure.
We investigated the effects of a diet low in saturated fat and cholesterol on serum lipid concentrations and growth in 1062 healthy 7-month-old infants in a randomised study.
Every 1-3 months, families in the intervention group received dietary advice aimed at adequate energy supply, with low fat intake (30-35% energy, polyunsaturated/monounsaturated/saturated fatty acid ratio 1/1/1, and cholesterol intake<200 mg daily).
Infants in control families consumed an unrestricted diet. 3-day food records were collected at ages 8 and 13 months.
Growth was carefully monitored.
Between 7 and 13 months serum cholesterol and non-high-density-lipoprotein cholesterol concentrations did not change significantly in the intervention group (mean change - 0.03 [SD 0.72] mmol/L and 0.01 [0.67] mmol/L) but increased substantially in the control group (0.24 [0.64] mmol/L and 0.23 [0.60] mmol/L ; p for difference in mean changes between groups<0.001).
Daily intakes of energy and saturated fat were lower in the intervention than in the control group at 13 months (4065  vs 4370  kJ, p=0.033, and 9.3 [3.5] vs 14.5 [4-8] g, p<0.001, respectively), and intake of polyunsaturated fat was higher (5.8 [2.2] vs 4.4 [1.4] g, p<0.001).
Mots-clés Pascal : Prévention, Homme, Nourrisson, Etude comparative, Régime alimentaire restrictif, Acide gras saturé, Cholestérol, Essai thérapeutique contrôlé, Randomisation, Finlande, Europe
Mots-clés Pascal anglais : Prevention, Human, Infant, Comparative study, Restricted diet, Saturated fatty acid, Cholesterol, Controlled therapeutic trial, Randomization, Finland, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0177135
Code Inist : 002B02A06. Création : 09/06/1995.