To estimate the rate and means of suicide among people taking 10 commonly prescribed antidepressant drugs : dothiepin, amitriptyline, clomipramine, imipramine, flupenthixol, lofepramine, mianserin, fluoxetine, doxepin, and trazodone.
Design-Open cohort study with a nested casecontrol analysis.
Setting-General practices in the United Kingdom that used YAMP computers to maintain their patient records from January 1988 to February 1993.
Subjects-172 598 people who had at least one prescription for one of the 10 antidepresssants during the study period.
Main outcome measure-Suicide confirmed by general practitioner or on death certificate, or both.
143 people committed suicide.
The overall rate of suicide was estimated to be 8.5 per 10 000 person years (95% confidence interval 7.2 to 10.0).
Rates of suicide were higher in men than women (relative risk 2.8 (95% confidence interval 1.9 to 4.0)), people with a history offeeling suicidal (19.2 (9.5 to 38.7)), and people who had taken several different antidepressants (2.8 (1.8 to 4.3)). People who received high doses of antidepressants and those who had had a prescription in the 30 days before they committed suicide were also at higher risk than those who had received low doses and had had their prescriptions 30 or more days previously (2.3 (1.4 to 3.7) and 2.3 (1.6 to 3.4)) respectively.
Mots-clés Pascal : Facteur risque, Traitement, Homme, Suicide, Antidépresseur, Chimiothérapie, Association
Mots-clés Pascal anglais : Risk factor, Treatment, Human, Suicide, Antidepressant agent, Chemotherapy, Association
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0170053
Code Inist : 002B02B02. Création : 09/06/1995.