Prostate cancer occurs more frequently in U.S. blacks than whites.
A population-based case-control study which investigated the association with family history of cancer was carried out among 981 men (479 black, 502 white) with pathologically confirmed prostate cancer, diagnosed between August 1,1986, and April 30,1989, and 1,315 controls (594 black, 721 white).
Study subjects, aged 4079, resided in Atlanta, Detroit, and 10 counties in New Jersey, geographic areas covered by population-based cancer registries.
Prostate cancer risk was significantly elevated among those who reported a history of prostate cancer in first-degree relatives (O. R=3.2 ; 95% C.I. : 2.05.0), with blacks and whites having similarly elevated risks.
These risks were unchanged by statistical adjustment for job-related socio-economic status, education, income, and marital status.
Overall, the ORs associated with history of prostate cancer in fathers and brothers were 2.5 (95% C.I. : 1.5-4.2) and 5.3 (95% C.I. : 2.3-12.5), respectively.
Risks associated with a family history of prostate cancer were consistently elevated among younger and older subjects.
Only small non-significant excesses of prostate cancer risk were associated with a family history of breast, colorectal, or other cancers.
Mots-clés Pascal : Tumeur maligne, Prostate, Facteur risque, Histoire familiale, Négroïde, Caucasoïde, Race, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Prostate pathologie, Appareil urinaire pathologie, Appareil génital mâle pathologie
Mots-clés Pascal anglais : Malignant tumor, Prostate, Risk factor, Family story, Negroid, Caucasoid, Race, Epidemiology, United States, North America, America, Human, Prostate disease, Urinary system disease, Male genital diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0167846
Code Inist : 002B14D02. Création : 09/06/1995.