There has been concern about the role of analgesics in the development of renal-cell cancer, although a few studies have reported moderately elevated risks with regular or long-term use.
In a large international case-control study of renal-cell cancer we examined, among other hypotheses, the effect of phenacetin-containing and of other types of analgesics : paracetamol (acetaminophen), salicylates (mainly aspirin) and pyrazolones (e.g., antipyrine or phenazone).
Relative risks, adiusted for the effects of age, sex, body-mass index, tobacco smoking and study centre, were not significantly increased with intake of phenacetin, either when lifetime consumption was categorized at the level of =0.1 kg or when subjects were subdivided further by amount.
Nor were paracetamol, salicylates or pyrazolones linked with renal-cell cancer.
No consistently increasing risks with consumption level was found.
The lack of association was not altered by restricting analgesic use to that which occurred 5 or 10 years before the defined « cut-off » date or when analysis was restricted to exclusive users of a particular type of analgesic.
Mots-clés Pascal : Hypernéphrome, Epithélioma, Rein, Facteur risque, Epidémiologie, Analgésique, Phénacétine, Paracétamol, Salicylés, Toxicité, Carcinogène, Australie, Océanie, Danemark, Europe, Suède, Etats Unis, Amérique du Nord, Amérique, Allemagne, Homme, Appareil urinaire pathologie, Rein pathologie, Tumeur maligne, Pyrazolés, Etude cas témoin
Mots-clés Pascal anglais : Grawitz tumor, Carcinoma, Kidney, Risk factor, Epidemiology, Analgesic, Salicylates, Toxicity, Carcinogen, Australia, Oceania, Denmark, Europe, Sweden, United States, North America, America, Germany, Human, Urinary system disease, Renal disease, Malignant tumor, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0167839
Code Inist : 002B02U10. Création : 09/06/1995.