Two case-control studies, including 449 histologically confirmed cases of cervical intra-epithelial neoplasia (CIN) III and 425 controls, and 2 studies on invasive cervical cancer, involving 316 histologically confirmed cases and 330 population controls, were conducted in Colombia and Spain to assess the role of herpex simplex virus type 2 (HSV-2) in cervical neoplasia.
Antibodies to this virus were also measured in the sera of 931 husbands of cases and controls.
A serological assay using type-specific antigens, glycoprotein C for type I (gC-1) and glycoprotein G for type 2 (gG-2) was employed.
Immunoglobulin-G (IgG) sub-classes, IgG1 and IgG3, were measured in women positive for HSV-2 antibodies.
No increase in risk of CIN III or invasive cancer was found in women whose sera or whose husbands'sera were positive to HSV-2.
However, compared with women negative to HSV-2, the risk or CIN III progressively increased with increasing levels of IgG3.
The trend was statistically significant in Colombia.
There was also a statistically significant increasing trend in risk of invasive cancer with levels of IgG1 in Spain.
Mots-clés Pascal : Tumeur maligne, Col utérus, Facteur risque, Virose, Infection, Herpesvirus hominis 2, Alphaherpesvirinae, Herpesviridae, Virus, IgG, Immunoglobuline, Anticorps, Epidémiologie, Espagne, Europe, Colombie, Amérique du Sud, Amérique, Homme, Col utérus pathologie, Appareil génital femelle pathologie
Mots-clés Pascal anglais : Malignant tumor, Uterine cervix, Risk factor, Viral disease, Infection, Herpesvirus hominis 2, Alphaherpesvirinae, Herpesviridae, Virus, IgG, Immunoglobulins, Antibody, Epidemiology, Spain, Europe, Colombia, South America, America, Human, Uterine cervix diseases, Female genital diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0167807
Code Inist : 002B20C02. Création : 09/06/1995.