A cohort of 5,546 ulcerative colitis patients was identified from the Danish Hospital Discharge Register for 1977-1989.
Patients not included in the cohort comprised those with proctitis, those treated in outpatient clinics and those for whom follow-up was less than 1 year.
The cohort was linked to the Danish Cancer Registry in order to assess the risks for colorectal and other cancers.
The linkage revealed a significant increase in the number of colorectal cancers over that in the general population (RR=1.8 ; n=42 ; 95% CI=1.3-2.4) with consistent relative risks during early and late follow-up.
The relative risk was considerably higher among younger (20-39 years : RR=22 ; n=8 ; 95% CI=9.7-44) than older patients (=60 years : RR=1.3 ; n=25 ; 95% CI=0.8-1.9), but the risk difference between patients and the general population was approximately constant across all ages.
In addition, we observed a significant increase in the relative risk of hepatobiliary cancers (RR=2.3 ; n=9 ; 95%=1.0-4.3) and a slight but significant increase in the relative risk of non-melanoma skin cancer (RR=1.4 ; n=37 ; 95% CI=1.0-1.9).
In summary, our population-based study confirms the increased risk of colorectal cancer among patients with ulcerative colitis and provides new leads suggesting that hepatobiliary cancer and non-melanoma skin cancer should be considered as possible sites for future patient monitoring.
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Facteur risque, Epidémiologie, Danemark, Europe, Rectocolite ulcérohémorragique, Etude cohorte, Homme, Côlon pathologie, Rectum pathologie, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Risk factor, Epidemiology, Denmark, Europe, Ulcerative colitis, Cohort study, Human, Colonic disease, Rectal disease, Digestive diseases, Intestinal disease, Inflammatory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0166201
Code Inist : 002B13B01. Création : 09/06/1995.