The relationship between renal-cell cancer (RCC) and tobacco use was investigated in an international, multicenter, population-based case-control study.
Coordinated studies were conducted in Australia, Denmark, Germany, Sweden and the United States using a shared protocol and questionnaire.
A total of 1,732 cases (1,050 men, 682 women) and 2,309 controls (1,429 men, 880 women) were interviewed for the study.
No association was observed between risk and use of cigars, pipes or smokeless tobacco.
A statistically significant association was observed for cigarette smoking, with current smokers having a 40% increase in risk [relative risk (RR)=1.4,95% confidence interval (CI) 1.2-1.7]. Risk increased with intensity (number of cigarettes) and duration (years smoked).
Among current smokers the RR for pack-years rose from 1.1 (95% CI 0.8-1.5) for<15.9 pack years to 2.0 (95% CI 1.6-2.7) for>42 pack years (p for trend<0.001).
Long term quitters (>15 years) experienced a reduction in risk of about 15-25% relative to current smokers.
Those who started smoking late (>24 years of age) had about two-thirds the risk of those who started young (¾12 years of age).
Overall, the findings of this pooled analysis confirm that cigarette smoking is a causal factor in the etiology of RCC.
Mots-clés Pascal : Hypernéphrome, Epithélioma, Rein, Facteur risque, Epidémiologie, Australie, Océanie, Danemark, Europe, Allemagne, Suède, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil urinaire pathologie, Rein pathologie, Tumeur maligne, Etude cas témoin
Mots-clés Pascal anglais : Grawitz tumor, Carcinoma, Kidney, Risk factor, Epidemiology, Australia, Oceania, Denmark, Europe, Germany, Sweden, United States, North America, America, Human, Urinary system disease, Renal disease, Malignant tumor, Case control study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0166077
Code Inist : 002B14D01. Création : 09/06/1995.