The theory that cancer may arise under conditions of reduced immune capacity is supported by observations of humans with immune deficiencies such as occur following organ transplants.
However, no study on humans has been done in which the reference population was the same as that in which the cancer cases arose and in which there was a sufficiently long period of follow-up.
Information on 5,692 Nordic recipients of renal transplants in 1964-1982 was linked with the national cancer registries (1964-1986) and population registries.
Person-years at risk were calculated from the date of first transplantation until death or the end of the study period and were multiplied by the appropriate age-and calender-specific incidence rates to obtain the expected numbers of cancers.
Standardized incidence ratios (SIR) were calculated after stratification by a number of recorded variables.
Altogether, 32,392 person-years were accrued, and 471 cancers occurred, yielding overall SIR of 4.6 (95% CI, 4.0 to 5.2) for males and 4.5 (95% CI, 4.0 to 5.2) for females.
Significant overall 2-to 5-fold excess risks in both sexes were seen for cancers of the colon, larynx, lung and bladder, and in men also for cancers of the prostate and testis.
Mots-clés Pascal : Tumeur maligne, Lymphome non hodgkinien, Facteur risque, Epidémiologie, Pays Scandinaves, Europe, Homotransplantation, Rein, Homme, Lymphoprolifératif syndrome, Hémopathie maligne, Transplantation, Chirurgie
Mots-clés Pascal anglais : Malignant tumor, Non Hodgkin lymphoma, Risk factor, Epidemiology, Scandinavia, Europe, Homotransplantation, Kidney, Human, Lymphoproliferative syndrome, Malignant hemopathy, Transplantation, Surgery
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0166074
Code Inist : 002B04B. Création : 09/06/1995.