In this retrospective study, 470 patients with non-Hodgkin's lymphoma (NHL) who had been followed in the Hacettepe University Medical Oncology Department between 1973 and 1990, were evaluated to establish their epidemiologic, clinical and therapeutic characteristics.
Out of 470 patients, 302 (62.2%) were male and 168 (37.8%) were female.
The ages ranged from 16 to 85, with a median of 44 years.
Constitutional symptoms were present in 46.4% of the patients.
According to the Working Formulation, low, intermediate, and high-grade lymphomas comprised 33.4%, 54.9%, and 12.7%, respectively.
The most common extranodal presentation was gastrointestinal.
The chemotherapy regimens most commonly used were CVP (cyclophosphide, vincristine, prednisone), BCNOP (bleomycin, cyclophosphamide, mitoxantrone, vincristine, prednisone), CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) and CHOP-Bleo (cyclophosphamide, doxorubicin, vincristine, prednisone, bleomycin).
The response rates and the survival figures attained with these regimens were not statistically significantly different (P>0.05).
In the Cox multivariate model, pathologic grade, leukopenia, responsiveness to chemotherapy, bone marrow involvement and age were the important factors influencing the disease-free survival, while responsiveness to chemotherapy, age, presence of constitutional symptoms, pathologic grade, extranodal presentation and stage were the important factors influencing the overall survival.
Mots-clés Pascal : Lymphome non hodgkinien, Diagnostic, Anticancéreux, Chimiothérapie, Traitement, Epidémiologie, Pronostic, Turquie, Asie, Rétrospective, Etude longitudinale, Homme, Hémopathie maligne, Lymphoprolifératif syndrome
Mots-clés Pascal anglais : Non Hodgkin lymphoma, Diagnosis, Antineoplastic agent, Chemotherapy, Treatment, Epidemiology, Prognosis, Turkey, Asia, Retrospective, Follow up study, Human, Malignant hemopathy, Lymphoproliferative syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0162136
Code Inist : 002B19B. Création : 09/06/1995.