Toxicological and chemical evaluation of emissions from carpet samples.
This study investigated findings that the off-gassing of certain carpets caused sensory and pulmonary irritation, changes in neurobehavioral signs, and death in exposed mice.
Two standard test method measures - one for estimating sensory irritancy (ASTM-E981-84), the other for evaluating the neurotoxic potential of chemicals (functional observational battery) - were coupled with a postmortem assessment to ascertain the mechanism of toxicity.
The postmortem evaluation included measurements of hemoglobin, serum clinical chemistries, blood and lung lavage white cell counts and differential, organ weights, and a gross necropsy with a microscopic evaluation of all major organs.
The study evaluated three treatment groups composed of two preheated carpet emission exposures and one preheated air-control exposure.
No toxic effects were associated with exposure to the off-gassing of the two tested carpets.
Clinical chemistry and histopathological alterations were observed with exposure to either filter-air or carpet when compared to nonexposed unrestrained control mice, indicating that the exposure procedure caused significant effects unrelated to carpet emissions.
A detailed chemical and microbial evaluation of the carpets and carpet emissions showed volatile organic compounds, pesticide residues, and microbiological flora, but at insufficient quantities to result in acute toxicity.
Mots-clés Pascal : Tapis, Composé volatil, Pesticide, Résidu, Flore associée, Microorganisme, Toxicité, Homme, Souris, Rodentia, Mammalia, Vertebrata, Animal, Inhalation, Chambre observation, Appareillage, Méthode étude
Mots-clés Pascal anglais : Carpet, Volatile compound, Pesticides, Residue, Associated flora, Microorganism, Toxicity, Human, Mouse, Rodentia, Mammalia, Vertebrata, Animal, Inhalation, Exposure chamber, Instrumentation, Investigation method
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 95-0149552
Code Inist : 002B03L03. Création : 09/06/1995.