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  1. Scientific and ethical aspects of genetic screening of workers for cancer risk : the case of the N-acetyltransferase phenotype.

    Article - En anglais

    Our expanding capacity to detect human genetic susceptibility to various chronic diseases presents us with the opportunity to screen asymptomatic people for purposes of employment, insurance or credit.

    It also brings with it the responsibility of deciding the ethical and social value of such applications.

    This paper addresses scientific and ethical issues involved in the use of genetic screening techniques which intend to identify individuals that have more than average susceptibiIity to develop cancer from workplace chemical exposures.

    The case in point is the genetic polymorphism for N-acetyltransferase activity and the risk of bladder cancer in workers exposed to carcinogenic arylamines.

    The acetyltransferase polymorphism is related to the metabolic activation and deactivation of carcinogenic arylamines.

    Any genetic screening test for cancer susceptibility must be based upon sound science.

    For example, it must be demonstrated that a specific metabolic phenotype is a risk factor for cancer and, further, that the available tests accurately classify the subjects as to the phenotype.

    If there is a poor correspondence between phenotype and genotype, or a large intra-individual variability in phenotype, misclassification may result.

    Also, bias, arising as a consequence of enzyme induction by specific substrates, must be ruled out.

    Genetic screening of workers for susceptibility to cancer seems to us an ethically unacceptable and premature, application of the science.

    Mots-clés Pascal : Dépistage, Déterminisme génétique, Tumeur maligne, Vessie urinaire, Exposition professionnelle, Carcinogène, Arylamine, Technique, Toxicogénétique, Ethique, Critère sélection, Employé, Risque élevé, Médecine travail, Etats Unis, Homme, Arylamine N-acetyltransferase, Amérique du Nord, Amérique, Acyltransferases, Transferases, Enzyme, Voie urinaire pathologie, Appareil urinaire pathologie

    Mots-clés Pascal anglais : Medical screening, Genetic inheritance, Malignant tumor, Urinary bladder, Occupational exposure, Carcinogen, Arylamine, Technique, Toxicogenetics, Ethics, Selection criterion, Employee, High risk, Occupational medicine, United States, Human, Arylamine N-acetyltransferase, North America, America, Acyltransferases, Transferases, Enzyme, Urinary tract disease, Urinary system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0149202

    Code Inist : 002B30A09. Création : 09/06/1995.