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  1. Exces cardiovascular and suicide mortality of affective disorders may be reduced by lithium prophylaxis.

    Article - En anglais

    The mortality of patients suffering from affective disorders is much higher than that of the general population ; this excess is due to both suicides and cardiovascular disease.

    During long-term lithium treatment, the overall mortality has not been found to differ significantly from that of the general population but the question remains whether this Lowering, if it is in fact caused by lithium, is due to a reduction in suicide frequency or cardiovascular mortality, or both.

    We analysed data from 827 previously studied patients and used a procedure that estimated both overall mortality and cause-specific mortalities by single-case analysis.

    For overall mortality, the ratio of observed deaths (among the patients) to expected deaths (in the general population) was 1.14, which is not significantly different from 1.0 ; this was also found in our previous analysis.

    In the whole patient group, comprising 5600 patient years under lithium treatment, seven suicides were observed and 1.3 expected, resulting in a standard mortality ratio of 5.22 ; this is significantly>1.0, but markedly lower than that found in patients with affective disorders not given lithium.

    Cardiovascular mortality was not found to be higher in our patients than in the general population.

    Mots-clés Pascal : Etat dépressif, Trouble humeur, Prévention, Chimiothérapie, Traitement, Lithium, Psychotrope, Suicide, Mortalité, Appareil circulatoire pathologie, Homme

    Mots-clés Pascal anglais : Depression, Mood disorder, Prevention, Chemotherapy, Treatment, Lithium, Psychotropic, Suicide, Mortality, Cardiovascular disease, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 95-0149152

    Code Inist : 002B02B02. Création : 09/06/1995.